Antibiotic therapy versus appendicectomy.

[Argirios Argiriou]

British Journal of Surgery
Volume 96 Issue 5, Pages 473 - 481
Published Online: 8 Apr 2009

Randomized clinical trial of antibiotic therapy versus appendicectomy as primary treatment of acute appendicitis in unselected patients.
J. Hansson 1, U. Körner 1, A. Khorram-Manesh 3, A. Solberg 2, K. Lundholm 1 *
1Department of Surgery, Sahlgrenska, Gothenburg, Sweden
2Department of Surgery, ¨Ostra University Hospitals, Gothenburg, Sweden
3Department of Surgery, Kungälv Hospital, Kungälv, Sweden
 
email: K. Lundholm (Kent.lundholm@surgery.gu.se)

*Correspondence to K. Lundholm, Department of Surgery, Sahlgrenska University Hospital, SE 413 45 Gothenburg, Sweden

Funded by:
 Region Västra Götaland

Abstract

Background:
A trial in selected men suggested that antibiotic therapy could be an alternative to appendicectomy in appendicitis. This study aimed to evaluate antibiotic therapy in unselected men and women with acute appendicitis.

Methods:
Consecutive patients were allocated to study (antibiotics) or control (surgery) groups according to date of birth. Study patients received intravenous antibiotics for 24 h and continued at home with oral antibiotics for 10 days. Control patients had a standard appendicectomy. Follow-up at 1 and 12 months was carried out according to intention and per protocol.

Results:
Study and control patients were comparable at inclusion; 106 (52·5 per cent) of 202 patients allocated to antibiotics completed the treatment and 154 (92·2 per cent) of 167 patients allocated to appendicectomy had surgery. Treatment efficacy was 90·8 per cent for antibiotic therapy and 89·2 per cent for surgery. Recurrent appendicitis occurred in 15 patients (13·9 per cent) after a median of 1 year. A third of recurrences appeared within 10 days and two-thirds between 3 and 16 months after hospital discharge. Minor complications were similar between the groups. Major complications were threefold higher in patients who had an appendicectomy (P < 0·050).

Conclusion:
Antibiotic treatment appears to be a safe first-line therapy in unselected patients with acute appendicitis. Registration number: NCT00469430 (Δεν είναι ορατοί οι σύνδεσμοι (links). Εγγραφή ή Είσοδος).

Copyright © 2009 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.



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Accepted: 26 February 2009
Digital Object Identifier (DOI)

10.1002/bjs.6482  About DOI




Δεν είναι ορατοί οι σύνδεσμοι (links). Εγγραφή ή Είσοδος

[Argirios Argiriou]

May 27, 2014

Two Studies Offer More Support for Nonoperative Management of Uncomplicated Appendicitis.


McCutcheon BA et al. Long-term outcomes of patients with nonsurgically managed uncomplicated appendicitis. J Am Coll Surg 2014 May; 218:905. (Δεν είναι ορατοί οι σύνδεσμοι (links). Εγγραφή ή Είσοδος)

Minneci PC et al. Feasibility of a nonoperative management strategy for uncomplicated acute appendicitis in children. J Am Coll Surg 2014 Apr 12; [e-pub ahead of print]. (Δεν είναι ορατοί οι σύνδεσμοι (links). Εγγραφή ή Είσοδος)
- See more at: Δεν είναι ορατοί οι σύνδεσμοι (links). Εγγραφή ή Είσοδος