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Clinical Reviews.

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Argirios Argiriou:
Κλινικές ανασκοπήσεις.

Argirios Argiriou:
Summary points:

Wound management is as important as use of antimicrobials in preventing infection.

Primary closure should be avoided in limb injuries where possible because of increased risk of infection.

For patients considered to be at higher risk of infection, the prophylaxis of choice is co-amoxiclav.

Erythromycin or flucloxacillin should never be used alone prophylactically as Pasteurella infection is usually resistant.

Infected wounds presenting within 12 hours of injury are usually due to Pasteurella multocida.

Patients at particularly high risk of infection are immunosuppressed patients, particularly those with asplenia or cirrhosis or those who have had a mastectomy.


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Argirios Argiriou:
Summary points:

Trigeminal neuralgia is a rare but characteristic pain syndrome.

Most cases are still referred to as idiopathic, although many are associated with vascular compression of the trigeminal nerve.

A minority of cases are symptomatic of multiple sclerosis or nerve compression by tumour.

The condition is variable and patients may have just one episode.

Most patients respond well to drugs; carbamazepine is usually the first line treatment.

If drug treatment fails or is not tolerated, surgical treatments are available.

Ablative surgical treatments are associated with facial sensory loss, almost no risk of severe complications or death, and a high rate of pain recurrence; microvascular decompression has a risk of severe complications or death, albeit very low, and a lower relapse rate.



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Argirios Argiriou:
Summary points:

Intermittent claudication is a common condition and in most cases is easily diagnosed.

It is associated with a significantly increased risk of death from cardiovascular disease.

Only a small proportion of patients with claudication require revascularisation.

The main treatment aim is to reduce the risk of mortality from cardiovascular events.

Smoking cessation, control of hypertension and diabetes, and prescription of statins and antiplatelet drugs are key elements for treating the condition.

Exercise, angioplasty, and bypass surgery can improve symptoms of claudication.



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Argirios Argiriou:
Summary points:

Atopic eczema is an itchy inflammatory skin condition with associated epidermal barrier dysfunction.

The prevalence of atopic eczema seems to be rising, but the factors responsible for this rise are not fully understood.

The pathophysiology of eczema involves systemic as well as cutaneous immune and epidermal dysfunction.

Eczema is a complex trait with significant genetic and environmental influences.

Emollients and topical steroids are the mainstay of treatment for mild to moderate eczema; moderate to severe eczema may require the addition of second line agents such as topical or systemic calcineurin inhibitors, ultraviolet phototherapy, or systemic azathioprine.

A clearer understanding of the genetic basis and pathophysiology of eczema is expected to lead to new improved treatments.



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