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Sertraline/mirtazapine for depression in dementia?

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Argirios Argiriou:
The Lancet, Volume 378, Issue 9789, Pages 403 - 411, 30 July 2011


Published Online: 18 July 2011

Sertraline or mirtazapine for depression in dementia (HTA-SADD): a randomised, multicentre, double-blind, placebo-controlled trial.

Prof Sube Banerjee MD a Corresponding AuthorEmail Address, Jennifer Hellier MSc b, Michael Dewey PhD a, Renee Romeo PhD a, Clive Ballard MD c, Robert Baldwin MD d, Peter Bentham MRCPsych e, Chris Fox MD f, Clive Holmes PhD g, Cornelius Katona MD h, Martin Knapp PhD a, Claire Lawton FRCPsych i, James Lindesay DM j, Gill Livingston MD h, Niall McCrae PhD a, Esme Moniz-Cook PhD k, Joanna Murray MA a, Shirley Nurock MSc l, Martin Orrell PhD h, John O'Brien DM m, Michaela Poppe PhD a, Alan Thomas PhD m, Rebecca Walwyn PhD b, Kenneth Wilson MD n, Alistair Burns MD d

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Interpretation
Because of the absence of benefit compared with placebo and increased risk of adverse events, the present practice of use of these antidepressants, with usual care, for first-line treatment of depression in Alzheimer's disease should be reconsidered.

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