Χρόνια χρήση PPIs

[GirousisN]

Long-term kidney outcomes among users of proton pump inhibitors without intervening acute kidney injury.

Proton pump inhibitor (PPI) use is associated with an increased risk of acute kidney injury (AKI), incident chronic kidney disease (CKD), and progression to end-stage renal disease (ESRD). PPI-associated CKD is presumed to be mediated by intervening AKI. However, whether PPI use is associated with an increased risk of chronic renal outcomes in the absence of intervening AKI is unknown. To evaluate this we used the Department of Veterans Affairs national databases to build a cohort of 144,032 incident users of acid suppression therapy that included 125,596 PPI and 18,436 Histamine H2 receptor antagonist (H2 blockers) consumers.
Over 5 years of follow-up in survival models, cohort participants were censored at the time of AKI occurrence. Compared with incident users of H2 blockers, incident users of PPIs had an increased risk of an estimated glomerular filtration rate (eGFR) under 60 ml/min/1.73m2 (hazard ratio 1.19), incident CKD (ΗR1.26), eGFR decline over 30% (HR 1.22), and ESRD or eGFR decline over 50% (HR 1.30).

Δεν είναι ορατοί οι σύνδεσμοι (links). Εγγραφή ή Είσοδος

[Argirios Argiriou]

31-10-2017

Gastric cancer risk doubles with long term PPI use.


Δεν είναι ορατοί οι σύνδεσμοι (links). Εγγραφή ή Είσοδος