Evolution and expansion of multidrug-resistant malaria in southeast Asia.

[Argirios Argiriou]

The Lancet. Infectious Diseases.
22 July 2019.

Evolution and expansion of multidrug-resistant malaria in southeast Asia: a genomic epidemiology study.

Interpretation

After emerging and circulating for several years within Cambodia, the P falciparum KEL1/PLA1 co-lineage diversified into multiple subgroups and acquired new genetic features, including novel crt mutations. These subgroups have rapidly spread into neighbouring countries, suggesting enhanced fitness. These findings highlight the urgent need for elimination of this increasingly drug-resistant parasite co-lineage, and the importance of genetic surveillance in accelerating malaria elimination efforts.

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