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Κορονοϊός ( COVID-19 )

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Argirios Argiriou:
A Comparison of Three Sample Types for COVID-19 Diagnosis

Thomas Glück, MD reviewing Hanson KE et al. J Clin Microbiol 2020 Aug 12

Saliva and healthcare worker–collected nasopharyngeal swabs performed similarly to each other and numerically better than self-collected nasal swabs.

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Argirios Argiriou:
The New York Times.

“Today, all of the European countries are more or less following the Swedish model, combined with the testing, tracing and quarantine procedures the Germans have introduced, but none will admit it,” said Antoine Flahault, director of the Institute of Global Health, in Geneva. “Instead, they made a caricature out of the Swedish strategy. Almost everyone has called it inhumane and a failure.”

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Argirios Argiriou:
October 1, 2020

Quantitating COVID-19 Fatality Rates

Abigail Zuger, MD reviewing Blackburn J et al. Ann Intern Med 2020 Sep 2 Menachemi N et al. MMWR Morb Mortal Wkly Rep 2020 Jul 24

Risk for death varied with age, race, and ethnicity, but in the absence of comorbidity data, patterns were not clarified.

Efforts to get an accurate estimate of the mortality linked to COVID-19 have been handicapped by erratic testing patterns, large numbers of asymptomatic carriers, and clear age-related differences in severity of illness. Indiana researchers now have calculated specific infection fatality ratios (IFRs) using data from a statewide point-prevalence study among community-dwelling residents, many of whom were asymptomatic.

At the end of April 2020, SARS-CoV-2 polymerase chain reaction (PCR) and antibody testing were performed on a random sample of >3600 noninstitutionalized Indiana residents (age, ≥12) as well as an additional 900 nonrandomly recruited individuals enrolled to broaden the sample's racial and ethnic diversity. Almost 40% of PCR-positive people were asymptomatic at testing. Correlation with the state's vital statistics data enabled calculation of a general IFR of 0.26% (a number valid for noninstitutionalized individuals only). More-specific estimates yielded IFRs of 0.01% (age, <40), 0.12% (age range, 40–59), and 1.71% (age, ≥60). Estimated IFR was higher for nonwhites than whites (0.59% vs. 0.18%), higher for non-Hispanics than Hispanics (0.34% vs. 0.04%), and slightly higher for men than women (0.28% vs. 0.21%).

COMMENT
Exclusion of children, incarcerated individuals, and nursing home residents makes these numbers, like previous ones, imperfect approximations. Further, without comorbidity adjustments, the data will not be very helpful for constructing individual prognoses. Still, they represent an interesting attempt to delineate a profile of disease severity — and the attendant public health challenges — within a single large geographic area. (Any comparison with influenza mortality will be invalid, as influenza prevalence data do not include asymptomatic people.)

EDITOR DISCLOSURES AT TIME OF PUBLICATION
Disclosures for Abigail Zuger, MD at time of publication
Nothing to disclose   
CITATION(S):
Blackburn J et al. Infection fatality ratios for COVID-19 among noninstitutionalized persons 12 and older: Results of a random-sample prevalence study. Ann Intern Med 2020 Sep 2; [e-pub]. (Δεν είναι ορατοί οι σύνδεσμοι (links). Εγγραφή ή Είσοδος)

Menachemi N et al. Population point prevalence of SARS-CoV-2 infection based on a statewide random sample — Indiana, April 25–29, 2020. MMWR Morb Mortal Wkly Rep 2020 Jul 24; 69:960. (Δεν είναι ορατοί οι σύνδεσμοι (links). Εγγραφή ή Είσοδος)

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Argirios Argiriou:
Αντιγράφω τον τοίχο συναδέλφου στο facebook:

Θνησιμότητα από γρίπη και κορωνοιό ανά ηλικιακή ομάδα - στοιχεία των ΗΠΑ.

Argirios Argiriou:
Αντιγράφω από συνάδελφο στο facebook στις 02/10/2020 (δεν αμφισβητώ ότι ο Κοροναϊός είναι πιο επιθετικός γενικά από την Γρίπη, ωστόσο έχει και τα δίκια του ο συνάδελφος):

χαιρετε, εκθεση ΕΟΔΥ 2018-19, σελιδα 24, ΕΚΤΙΜΩΜΕΝΟΙ ΘΑΝΑΤΟΙ ΑΠΟ ΓΡΙΠΠΗ ΤΑ ΤΕΛΕΥΤΑΙ 6 ΧΡΟΝΙΑ, ΤΟ 2014 ΕΙΧΑΜΕ 4ΟΟΟ αλλα δεν εκλεισε η χώρα..... υποτιθεται σε 6μηνες ετοιμαστηκε η ΥΓΕΙΑ-ΜΕΘ, αλλα.......

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