Comparison of Acetaminophen (Paracetamol) With Ibuprofen for Treatment of Fever

[Argirios Argiriou]

JAMA, October 30, 2020

Comparison of Acetaminophen (Paracetamol) With Ibuprofen for Treatment of Fever or Pain in Children Younger Than 2 Years
A Systematic Review and Meta-analysis

Key Points
Question  Are there differences in the antipyretic, analgesic, and safety profiles of acetaminophen (paracetamol) compared with ibuprofen for the short-term treatment of fever or pain in children younger than 2 years?

Findings  In this meta-analysis of 19 studies with 241 138 participants, ibuprofen, compared with acetaminophen, was associated with reduced temperature at less than 4 hours and 4 to 24 hours and less pain at 4 to 24 hours. Adverse events were uncommon.

Meaning  In this study, use of ibuprofen vs acetaminophen for the treatment of fever or pain in children younger than 2 years was associated with reduced temperature and less pain within the first 24 hours of treatment, with equivalent safety.

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