Forum Πρωτοβάθμιας Φροντίδας Υγείας
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JAMA, October 30, 2020
Comparison of Acetaminophen (Paracetamol) With Ibuprofen for Treatment of Fever or Pain in Children Younger Than 2 Years
A Systematic Review and Meta-analysis
Key Points
Question Are there differences in the antipyretic, analgesic, and safety profiles of acetaminophen (paracetamol) compared with ibuprofen for the short-term treatment of fever or pain in children younger than 2 years?
Findings In this meta-analysis of 19 studies with 241 138 participants, ibuprofen, compared with acetaminophen, was associated with reduced temperature at less than 4 hours and 4 to 24 hours and less pain at 4 to 24 hours. Adverse events were uncommon.
Meaning In this study, use of ibuprofen vs acetaminophen for the treatment of fever or pain in children younger than 2 years was associated with reduced temperature and less pain within the first 24 hours of treatment, with equivalent safety.
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2772373?fbclid=IwAR0agUe3z-eH5ckDcBpFe98Us3wlNZNChWv0psXr0Tpwi5jMBBw5jpQSH2w (https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2772373?fbclid=IwAR0agUe3z-eH5ckDcBpFe98Us3wlNZNChWv0psXr0Tpwi5jMBBw5jpQSH2w)